Article
Gain-of-function mutations in the extracellular domain of KIT are common in canine mast cell tumors.
Molecular cancer research : MCR - 1 Jul 2008
Letard Sébastien, Yang Ying, Hanssens Katia, Palmérini Fabienne, Leventhal Phillip S, Guéry Stéphanie, Moussy Alain, Kinet Jean-Pierre, Hermine Olivier, Dubreuil Patrice
Abstract excerpt
In the current study, we examined the types and frequency of KIT mutations in mast cell tumors from 191 dogs. Sequencing of reverse transcription-PCR products revealed alterations in 50 (26.2%) of the dogs. Most mutations were in exon 11 (n = 32), and of these, most were internal tandem duplications (n = 25) between residues 571 and 590. Within exon 11, there were two hotspots for mutations at codons 555-559 and...
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