Article
Germ-line expression of an oncogenic erbB2 allele confers resistance to erbB2-induced mammary tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America - 6 Apr 2004
Andrechek Eran R, Hardy William R, Laing Michael A, Muller William J
Abstract excerpt
We have previously shown that mammary epithelial specific expression of the activated erbB2 allele under the control of the endogenous promoter in mice resulted in the formation of mammary adenocarcinomas. To assess whether mammary tumorigenesis in this model is influenced by the developmental window of expression, we generated mice that expressed the activated erbB2 allele in the germ line. Although we were able...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.