Article
Induction of a variety of tumors by c-erbB2 and clonal nature of lymphomas even with the mutated gene (Val659----Glu659).
The EMBO journal - 1 Jan 1990
Suda Y, Aizawa S, Furuta Y, Yagi T, Ikawa Y, Saitoh K, Yamada Y, Toyoshima K, Yamamoto T
Abstract excerpt
The c-erbB2 gene is expressed uniquely in fetal epithelium in vivo and has been suggested to contribute to the development and/or progression of adenocarcinomas in man. In order to assess the oncogenicity of the c-erbB2 gene in vivo, normal c-erbB2 and mutant c-erbB2 encoding glutamic acid instead of valine at position 659 within the transmembrane domain were introduced into mice under the transcriptional...
Topics
- Adenocarcinoma
- Animals
- Animals, Newborn
- B-Lymphocytes
- Cell Line
- Cell Transformation, Neoplastic
- DNA
- DNA, Recombinant
- ErbB Receptors
- Gene Expression
- Harderian Gland