Article
T-cell proliferation and antitumour activities of a truncated mutant of staphylococcal enterotoxin C2 with decreased cytokine secretion.
Journal of medical microbiology - 1 Mar 2013
Zhou Junyi, Liu Li, Xu Mingkai, Zhang Huiwen, Zhang Yixuan, Zhang Chenggang
Abstract excerpt
As a superantigen, staphylococcal enterotoxin C2 (SEC2) has commonly been used as an antitumour immunotherapy agent in China. However, the clinical application of SEC2 has been hampered by its pyrogenic toxicity and the presence of neutralizing antibody in patients. Thus, an improvement in its superantigen-based immunotherapy is highly needed. In this study, a truncated SEC2 mutant, SEC(14-128), was constructed...
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