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Article

Protection of mice from Shiga toxin-2 toxemia by mucosal vaccine of Shiga toxin 2B-His with Escherichia coli enterotoxin.

Vaccine - 24 Jan 2008

Tsuji Takao, Shimizu Takeshi, Sasaki Keiko, Shimizu Yoshiyasu, Tsukamoto Kentaro, Arimitsu Hideyuki, Ochi Sadayuki, Sugiyama Satoshi, Taniguchi Koki, Neri Paola, Mori Hiroshi

Abstract excerpt

Escherichia coli O157:H7 produces Stx1 and Stx2 causing severe diseases. Their B subunits (StxBs) are useful for a vaccine but exhibit low immunogenicity, especially Stx2B. Nasal vaccination with StxBs plus cholera toxin induces only serum anti-Stx1B antibodies in mice. However, nasal administration of a mutant of E. coli enterotoxin and His-tagged Stx2B induced serum antibodies neutralizing Stx2 in vitro or in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18093704
DOI: 10.1016/j.vaccine.2007.11.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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