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Article

Possible epistatic role of ADH7 in the protection against alcoholism.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2004

Osier M V, Lu R-B, Pakstis A J, Kidd J R, Huang S-Y, Kidd Kenneth K

Abstract excerpt

In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His. Here we present evidence for an additional effect from outside the Class I ADH genes, presumably from functional variation at the ADH7 gene. The protective effect is restricted to one of two haplotypes identical at...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15048643
DOI: 10.1002/ajmg.b.20136

Genes

ADH7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Possible epistatic role of ADH7 in the protection against alcoholism.PMID 15048643Read ↗

Scanning of genetic effects of alcohol metabolism gene (ADH1B and ADH1C) polymorphisms on the risk of alcoholism.Semantic proximity Read ↗

Considerable haplotype diversity within the 23kb encompassing the ADH7 gene.Semantic proximity Read ↗

Association of the gastric alcohol dehydrogenase gene ADH7 with variation in alcohol metabolism.Semantic proximity Read ↗

Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model.Semantic proximity Read ↗

Protective variant associated with alcohol dependence in a Mexican American cohort.Semantic proximity Read ↗

Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population.Semantic proximity Read ↗

Evidence of positive selection on a class I ADH locus.Semantic proximity Read ↗

Identification of new single nucleotid polymorphisms (SNP) in alcohol dehydrogenase class IV ADH7 gene within a French population.Semantic proximity Read ↗

A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity.Semantic proximity Read ↗

Single-nucleotide polymorphisms interact to affect ADH7 transcription.Semantic proximity Read ↗

Ethnic related selection for an ADH Class I variant within East Asia.Semantic proximity Read ↗

Variation in the ADH1B proximal promoter affects expression.Semantic proximity Read ↗

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