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Article

Identification of a calcineurin-independent pathway required for sodium ion stress response in Saccharomyces cerevisiae.

Genetics - 1 Sept 1998

Ganster R W, McCartney R R, Schmidt M C

Abstract excerpt

The calcium-dependent protein phosphatase calcineurin plays an essential role in ion homeostasis in yeast. In this study, we identify a parallel ion stress response pathway that is independent of the calcineurin signaling pathway. Cells with null alleles in both STD1 and its homologue, MTH1, manifest numerous phenotypes observed in calcineurin mutants, including sodium, lithium, manganese, and hydroxyl ion...

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Identifiers

PMID: 9725828
DOI: 10.1093/genetics/150.1.31
PMCID: PMC1460325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Identification of a calcineurin-independent pathway required for sodium ion stress response in Saccharomyces cerevisiae.PMID 9725828Read ↗

Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase.Semantic proximity Read ↗

Ion tolerance of Saccharomyces cerevisiae lacking the Ca2+/CaM-dependent phosphatase (calcineurin) is improved by mutations in URE2 or PMA1.Semantic proximity Read ↗

A homolog of mammalian, voltage-gated calcium channels mediates yeast pheromone-stimulated Ca2+ uptake and exacerbates the cdc1(Ts) growth defect.Semantic proximity Read ↗

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Regulation of Trk-dependent potassium transport by the calcineurin pathway involves the Hal5 kinase.Semantic proximity Read ↗

Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae.Semantic proximity Read ↗

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Loss of Apm1, the micro1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast.Semantic proximity Read ↗

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