Article
Its8, a fission yeast homolog of Mcd4 and Pig-n, is involved in GPI anchor synthesis and shares an essential function with calcineurin in cytokinesis.
The Journal of biological chemistry - 27 Apr 2001
Yada T, Sugiura R, Kita A, Itoh Y, Lu Y, Hong Y, Kinoshita T, Shuntoh H, Kuno T
Abstract excerpt
In fission yeast, calcineurin is required for cytokinesis and ion homeostasis; however, most of its physiological roles remain obscure. To identify genes that share an essential function with calcineurin, we screened for mutations that confer sensitivity to the calcineurin inhibitor FK506 and high temperature and isolated the mutant its8-1. its8(+) encodes a homolog of the budding yeast MCD4 and human Pig-n that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.