Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An essential role of the yeast pheromone-induced Ca2+ signal is to activate calcineurin.

Molecular biology of the cell - 1 Feb 1997

Withee J L, Mulholland J, Jeng R, Cyert M S

Abstract excerpt

Previous studies showed that, in wild-type (MATa) cells, alpha-factor causes an essential rise in cytosolic Ca2+. We show that calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is one target of this Ca2+ signal. Calcineurin mutants lose viability when incubated with mating pheromone, and overproduction of constitutively active (Ca(2+)-independent) calcineurin improves the viability of wild-type...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to Cell Cycle
Share to Culture Media

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Mutation

Share to Peptides

Share to Saccharomyces cerevisiae

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 9190206
DOI: 10.1091/mbc.8.2.263
PMCID: PMC276078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An essential role of the yeast pheromone-induced Ca2+ signal is to activate calcineurin.PMID 9190206Read ↗

Fig1p facilitates Ca2+ influx and cell fusion during mating of Saccharomyces cerevisiae.Semantic proximity Read ↗

Loss of Apm1, the micro1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast.Semantic proximity Read ↗

A homolog of mammalian, voltage-gated calcium channels mediates yeast pheromone-stimulated Ca2+ uptake and exacerbates the cdc1(Ts) growth defect.Semantic proximity Read ↗

Ion tolerance of Saccharomyces cerevisiae lacking the Ca2+/CaM-dependent phosphatase (calcineurin) is improved by mutations in URE2 or PMA1.Semantic proximity Read ↗

Calcineurin as a multifunctional regulator: Unraveling novel functions in fungal stress responses, hyphal growth, drug resistance, and pathogenesisSemantic proximity Read ↗

Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase.Semantic proximity Read ↗

When and why an essential popular mineral—calcium—is an effective antifungal adjuvant against the human pathogen?Semantic proximity Read ↗

Differential regulation of two Ca(2+) influx systems by pheromone signaling in Saccharomyces cerevisiae.Semantic proximity Read ↗

Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases.Semantic proximity Read ↗

Calcineurin is essential for Candida albicans survival in serum and virulence.Semantic proximity Read ↗

Calcineurin inhibits VCX1-dependent H+/Ca2+ exchange and induces Ca2+ ATPases in Saccharomyces cerevisiae.Semantic proximity Read ↗

Calcium signaling is involved in dynein-dependent microtubule organization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.