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Article

An essential role of the yeast pheromone-induced Ca2+ signal is to activate calcineurin.

Molecular biology of the cell - 1 Feb 1997

Withee J L, Mulholland J, Jeng R, Cyert M S

Abstract excerpt

Previous studies showed that, in wild-type (MATa) cells, alpha-factor causes an essential rise in cytosolic Ca2+. We show that calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is one target of this Ca2+ signal. Calcineurin mutants lose viability when incubated with mating pheromone...

Topics

Biological Transport
Calcineurin
Calcium
Calmodulin-Binding Proteins
Cell Cycle
Cell Wall
Culture Media
Enzyme Activation
Mating Factor
Mutation
Peptides
Pheromones
Phosphoprotein Phosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Signal Transduction

Source

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Identifiers

PMID: 9190206
DOI: 10.1091/mbc.8.2.263
PMCID: PMC276078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9190206-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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