Article
DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy.
American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Apr 2004
Lord Graham M, Hollstein Monica, Arlt Volker M, Roufosse Candice, Pusey Charles D, Cook Terry, Schmeiser Heinz H
Abstract excerpt
BACKGROUND: Aristolochic acid-associated nephropathy (AAN) is a specific type of renal disease that predisposes patients to a high risk of urothelial carcinoma. The authors have analyzed DNA from a patient who had urothelial malignancy 6 years after presenting with AAN and later had a breast carcinoma that metastasized to the liver. METHODS AND RESULTS: DNA was isolated from the primary breast tumor, the liver...
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