Article
HLA-DRB1 alleles encoding the "shared epitope" are associated with susceptibility to developing rheumatoid arthritis whereas HLA-DRB1 alleles encoding an aspartic acid at position 70 of the beta-chain are protective in Mexican Mestizos.
Human immunology - 1 Mar 2004
Ruiz-Morales J A, Vargas-Alarcón G, Flores-Villanueva P O, Villarreal-Garza C, Hernández-Pacheco G, Yamamoto-Furusho J K, Rodríguez-Pérez J M, Pérez-Hernández N, Rull M, Cardiel M H, Granados J
Abstract excerpt
The risk to develop rheumatoid arthritis (RA) has been associated with the presence of HLA-DRB1 alleles encoding the "shared epitope" (SE). Additionally, HLA-DRB1 alleles encoding an aspartic acid at position 70 (D70+ ) have been associated with protection against the development of RA. In this study we tested the association between either SE or D70+ and rheumatoid arthritis in Mexican Mestizos. We included 84...
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