Article
Relevant residues of DRbeta1 third hypervariable region contributing to the expression and to severity of rheumatoid arthritis (RA) in Mexicans.
Human immunology - 1 May 1998
Debaz H, Olivo A, Vazquez Garcia M N, de la Rosa G, Hernandez A, Lino L, Burgos R, Fernandez-Viña M, Stastny P, Gorodezky C
Abstract excerpt
Rheumatoid arthritis (RA) is a chronic autoimmune disease leading to destruction of the joints. Residues at positions 67-74 of the DRB1 third hypervariable region are involved in susceptibility (S) and resistance (P) to RA. DNA from 83 patients and 175 controls, all of them Mexican Mestizos were oligotyped using PCR-SSOP and PCR-SSP. The (S) alleles are DRB*0404 (p = 0.000004), *0401 (p = 0.007) and *1001 (p =...
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