Article
Relevant residues of DRbeta1 third hypervariable region contributing to the expression and to severity of rheumatoid arthritis (RA) in Mexicans.
Human immunology - 1 May 1998
Debaz H, Olivo A, Vazquez Garcia M N, de la Rosa G, Hernandez A, Lino L, Burgos R, Fernandez-Viña M, Stastny P, Gorodezky C
Abstract excerpt
Rheumatoid arthritis (RA) is a chronic autoimmune disease leading to destruction of the joints. Residues at positions 67-74 of the DRB1 third hypervariable region are involved in susceptibility (S) and resistance (P) to RA. DNA from 83 patients and 175 controls, all of them Mexican Mestizos were...
Topics
- Adult
- Arthritis, Rheumatoid
- Autoimmune Diseases
- Disease Susceptibility
- Female
- Genotype
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Immunoglobulin Variable Region
- Indians, North American
- Male
- Mexico
- Middle Aged
- Polymerase Chain Reaction