Article
Role of HLA-DRB1*04 in the susceptibility and HLA-DRB1*08 in the protection for development of rheumatoid arthritis in a population of Southern Mexico: brief report.
Clinical rheumatology - 1 Oct 2020
Sepúlveda-Delgado J, Rizo-Pinto A, Granados-Arriola J, Mena-Vela B A, Cetina-Díaz J H, García-Silva R, Hernández-Doño S, Cruz-Salvatierra M A, Pérez-Tirado J M, Vázquez-Guzmán C, Dominguez-Arrevillaga S, Trujillo-Vizuet M G, Sanchez-González R A, Zamudio-Castellanos F, Vera-Lastra O L, Jara-Quezada L J
Abstract excerpt
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease with an increased prevalence in Mexico. Although its etiology is unknown, its development can be influenced by environmental factors such as smoking and viral infections. But among the factors influencing susceptibility, it is the genetic factors that predominate, mainly the HLA-DRB1 genes, and specifically the alleles that have the shared epitope...
Topics
- Alleles
- Arthritis, Rheumatoid
- Female
- Genetic Predisposition to Disease
- Genotype
- HLA-DRB1 Chains
- Humans
- Male
- Mexico