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Article

Different responses of macrophages to smooth and rough Brucella spp.: relationship to virulence.

Infection and immunity - 1 Apr 2004

Jiménez de Bagüés María P, Terraza Annie, Gross Antoine, Dornand Jacques

Abstract excerpt

By comparing smooth wild-type Brucella strains to their rough mutants, we show that the lipopolysaccharide (LPS) O side chain of pathogenic Brucella has a dramatic impact on macrophage activation. It favors the development of virulent Brucella by preventing the synthesis of immune mediators, important for host defense. We conclude that this O chain property is firmly linked to Brucella virulence.

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Identifiers

PMID: 15039375
DOI: 10.1128/IAI.72.4.2429-2433.2004
PMCID: PMC375206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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