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Article

Smooth to Rough Dissociation in Brucella: The Missing Link to Virulence.

Frontiers in cellular and infection microbiology - 1 Jan 2015

Mancilla Marcos

Abstract excerpt

Dissociation encompasses changes in a series of phenotypes: colony and cell morphology, inmunological and biochemical reactions and virulence. The concept is generally associated to the in vitro transition between smooth (S) and rough (R) colonies, a phenotypic observation in Gram-negative bacteria commonly made since the beginning of microbiology as a science. It is also well known that the loss of the...

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PMID: 26779449
DOI: 10.3389/fcimb.2015.00098
PMCID: PMC4700419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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