Article
Novel susceptibility locus at 22q11 for diabetic nephropathy in type 1 diabetes.
PloS one - 1 Jan 2011
Wessman Maija, Forsblom Carol, Kaunisto Mari A, Söderlund Jenny, Ilonen Jorma, Sallinen Riitta, Hiekkalinna Tero, Parkkonen Maija, Maxwell Alexander P, Tarnow Lise, Parving Hans-Henrik, Hadjadj Samy, Marre Michel, Peltonen Leena, Groop Per-Henrik
Abstract excerpt
BACKGROUND: Diabetic nephropathy (DN) affects about 30% of patients with type 1 diabetes (T1D) and contributes to serious morbidity and mortality. So far only the 3q21-q25 region has repeatedly been indicated as a susceptibility region for DN. The aim of this study was to search for new DN susceptibility loci in Finnish, Danish and French T1D families. METHODS AND RESULTS: We performed a genome-wide linkage study...
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