Article
Discovery of a Met300Val variant in Shc and studies of its relationship to birth weight and length, impaired insulin secretion, insulin resistance, and type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism - 1 Jun 1999
Almind K, Ahlgren M G, Hansen T, Urhammer S A, Clausen J O, Pedersen O
Abstract excerpt
The Shc adaptor proteins corresponding to the 46-, 52-, and 66-kDa isoforms are key transducers of growth promotion and gene expression, which are being phosphorylated by all known receptor tyrosine kinases after stimulation by growth factors such as insulin and insulin-like growth factor I. Several studies have demonstrated a relationship between intrauterine growth retardation and impaired glucose tolerance or...
Topics
- Adaptor Proteins, Signal Transducing
- Adaptor Proteins, Vesicular Transport
- Adult
- Birth Weight
- Blood Glucose
- Body Height
- Diabetes Mellitus, Type 2
- Female
- Heteroduplex Analysis
- Humans
- Infant, Newborn
- Insulin
- Insulin Resistance