Article
Molecular phenotyping of the mouse ky mutant reveals UCP1 upregulation at the neuromuscular junctions of dystrophic soleus muscle.
Neuromuscular disorders : NMD - 1 Mar 2004
Blanco G, Pritchard C, Underhill P, Breeds S, Townsend K M F, Greenfield A, Brown Steve D M
Abstract excerpt
The ky mutant mouse displays a muscular dystrophy that affects almost exclusively slow type muscles in which persistent muscle regeneration, neuromuscular junction instability and an absence of the hypertrophic response are prominent features. In order to gain insights into the pathogenesis of this muscular dystrophy we have undertaken RNA profiling of the extensor digitorum longus, a fast unaffected muscle, and...
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