Article
The kyphoscoliosis (ky) mouse is deficient in hypertrophic responses and is caused by a mutation in a novel muscle-specific protein.
Human molecular genetics - 1 Jan 2001
Blanco G, Coulton G R, Biggin A, Grainge C, Moss J, Barrett M, Berquin A, Maréchal G, Skynner M, van Mier P, Nikitopoulou A, Kraus M, Ponting C P, Mason R M, Brown S D
Abstract excerpt
The ky mouse mutant exhibits a primary degenerative myopathy preceding chronic thoraco-lumbar kyphoscoliosis. The histopathology of the ky mutant suggests that Ky protein activity is crucial for normal muscle growth and function as well as the maturation and stabilization of the neuromuscular junction. Muscle hypertrophy in response to increasing demand is deficient in the ky mutant, whereas adaptive fibre type...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.