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Article

C3KO mouse expression analysis: downregulation of the muscular dystrophy Ky protein and alterations in muscle aging.

Neurogenetics - 1 Nov 2012

Jaka Oihane, Kramerova Irina, Azpitarte Margarita, López de Munain Adolfo, Spencer Melissa, Sáenz Amets

Abstract excerpt

Mutations in CAPN3 gene cause limb-girdle muscular dystrophy type 2A (LGMD2A) characterized by muscle wasting and progressive degeneration of scapular and pelvic musculature. Since CAPN3 knockout mice (C3KO) display features of muscle pathology similar to those features observed in the earliest-stage or preclinical LGMD2A patients, gene expression profiling analysis in C3KO mice was performed to gain insight into...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22820870
DOI: 10.1007/s10048-012-0336-7

Genes

CAPN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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