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Article

Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk.

Diseases of the colon and rectum - 1 Oct 2008

Cleary Sean P, Kim Hyeja, Croitoru Marina E, Redston Mark, Knight Julia A, Gallinger Steven, Gryfe Robert

Abstract excerpt

PURPOSE: Whereas truncating germline mutations of the adenomatous polyposis coli (APC) gene give rise to familial adenomatous polyposis, missense polymorphisms of APC may confer a weaker risk for colorectal cancer. METHODS: We sequenced the entire open reading frame of the APC gene and tested for two common MYH mutations in a population-based series of patients with colorectal cancer and 5 to 99 adenomas....

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Identifiers

PMID: 18612690
DOI: 10.1007/s10350-008-9356-7
PMCID: PMC2768068

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APC

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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