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Article

Multiple Colorectal Adenomas, Classic Adenomatous Polyposis, and Germ-Line Mutations in<i>MYH</i>

27 Feb 2003

Abstract excerpt

BACKGROUND: Germ-line mutations in the base-excision-repair gene MYH have been associated with recessive inheritance of multiple colorectal adenomas. Tumors from affected persons displayed excess somatic transversions of a guanine-cytosine pair to a thymine-adenine pair (G:C-->T:A) in the APC gene. METHODS: We screened for germ-line MYH mutations in 152 patients with multiple (3 to 100) colorectal adenomas and...

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Identifiers

PMID: 12606733
DOI: 10.1056/nejmoa025283

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Related research

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Multiple Colorectal Adenomas, Classic Adenomatous Polyposis, and Germ-Line Mutations in<i>MYH</i>PMID 12606733Read ↗

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