Article
Evidence of linkage and association on chromosome 20 for late-onset Alzheimer disease.
Neurogenetics - 1 Jun 2004
Goddard Katrina A B, Olson Jane M, Payami Haydeh, van der Voet Monique, Kuivaniemi Helena, Tromp Gerard
Abstract excerpt
Recently, we reported evidence of linkage on chromosome 20 for Alzheimer disease (AD) using a novel statistical approach to incorporate covariates (e.g., age, ApoE genotype) into the analysis. These results suggest that very elderly subjects (>85 years), and individuals who carry an epsilon2 allele at the ApoE locus are more likely to be linked to this candidate region. The region on chromosome 20 includes a...
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