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Article

A copper chaperone-mimetic polytherapy for SOD1-associated amyotrophic lateral sclerosis.

The Journal of biological chemistry - 1 Mar 2022

McAlary L, Shephard V K, Wright G S A, Yerbury J J

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which motor neurons progressively and rapidly degenerate, eventually leading to death. The first protein found to contain ALS-associated mutations was copper/zinc superoxide dismutase 1 (SOD1), which is conformationally stable when it contains its metal ligands and has formed its native intramolecular disulfide. Mutations in SOD1 reduce protein...

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Identifiers

PMID: 35065969
DOI: 10.1016/j.jbc.2022.101612
PMCID: PMC8885447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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