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Article

Early interneuron dysfunction in ALS: Insights from a mutant sod1 zebrafish model

1 Oct 2012

Abstract excerpt

OBJECTIVE: To determine, when, how, and which neurons initiate the onset of pathophysiology in amyotrophic lateral sclerosis (ALS) using a transgenic mutant sod1 zebrafish model and identify neuroprotective drugs. METHODS: Proteinopathies such as ALS involve mutant proteins that misfold and activate the heat shock stress response (HSR). The HSR is indicative of neuronal stress, and we used a fluorescent...

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PMID: 23281025
DOI: 10.1002/ana.23780

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