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Article

Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development.

Cancer research - 1 Nov 2005

Dubé Nadia, Bourdeau Annie, Heinonen Krista M, Cheng Alan, Loy Ailsa Lee, Tremblay Michel L

Abstract excerpt

Protein tyrosine phosphatase 1B (PTP1B) is involved in multiple signaling pathways by down-regulating several tyrosine kinases. For example, gene-targeting studies in mice have established PTP1B as a critical physiologic regulator of metabolism by attenuating insulin signaling. PTP1B is an important target for the treatment of diabetes, because the PTP1B null mice are resistant to diet-induced diabetes and...

Read the complete abstract on PubMed

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Share to B-Lymphocytes
Share to Bone Marrow Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cells

Share to Lymph Nodes

Share to Lymphoma, B-Cell

Share to Mice, Inbred BALB C

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

Share to Protein Tyrosine Phosphatases

Source

Identifiers

PMID: 16267035
DOI: 10.1158/0008-5472.CAN-05-1353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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