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Article

Protein tyrosine phosphatase regulation in fibroblasts from patients with an insulin receptor gene mutation.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Dec 2008

Seki N, Yagi S, Suzuki Y, Shimada F, Taira M, Makino H, Amano K, Yagui K, Saito Y, Hashimoto N

Abstract excerpt

Tyrosine phosphorylation of the insulin receptor is the initial event following receptor binding to insulin, and it induces further tyrosine phosphorylation of various intracellular molecules. This signaling is countered by protein tyrosine phosphatases (PTPases), which reportedly are associated...

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Share to Gene Expression Regulation, Enzymologic
Share to Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin

Share to Insulin Resistance

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

Share to Protein Tyrosine Phosphatases

Share to Receptor, Insulin

Share to Stimulation, Chemical

Source

Identifiers

PMID: 18925540
DOI: 10.1055/s-0028-1082082

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18925540-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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