Article
Nodal and BMP2/4 signaling organizes the oral-aboral axis of the sea urchin embryo.
Developmental cell - 1 Mar 2004
Duboc Véronique, Röttinger Eric, Besnardeau Lydia, Lepage Thierry
Abstract excerpt
In the sea urchin embryo, the oral-aboral axis is specified after fertilization by mechanisms that are largely unknown. We report that early sea urchin embryos express Nodal and Antivin in the presumptive oral ectoderm and demonstrate that these genes control formation of the oral-aboral axis. Overexpression of nodal converted the whole ectoderm into oral ectoderm and induced ectopic expression of the orally...
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