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Article

Identification of transcripts potentially involved in neural tube closure using RNA sequencing.

Genesis (New York, N.Y. : 2000) - 1 Mar 2018

Kindt Lexy M, Coughlin Alicia R, Perosino Tianna R, Ersfeld Haley N, Hampton Marshall, Liang Jennifer O

Abstract excerpt

Anencephaly is a fatal human neural tube defect (NTD) in which the anterior neural tube remains open. Zebrafish embryos with reduced Nodal signaling display an open anterior neural tube phenotype that is analogous to anencephaly. Previous work from our laboratory suggests that Nodal signaling acts through induction of the head mesendoderm and mesoderm. Head mesendoderm/mesoderm then, through an unknown mechanism,...

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Identifiers

PMID: 29488319
DOI: 10.1002/dvg.23096
PMCID: PMC6616371

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