Article
The membrane raft protein Flotillin-1 is essential in dopamine neurons for amphetamine-induced behavior in Drosophila.
Molecular psychiatry - 1 Jul 2013
Pizzo A B, Karam C S, Zhang Y, Yano H, Freyberg R J, Karam D S, Freyberg Z, Yamamoto A, McCabe B D, Javitch J A
Abstract excerpt
The dopamine transporter (DAT) is the primary molecular target responsible for the rewarding properties of the psychostimulants amphetamine (AMPH) and cocaine. AMPH increases extracellular dopamine (DA) by promoting its nonexocytotic release via DAT-mediated efflux. Previous studies in heterologous cells have shown that phosphorylation of the amino terminus of DAT is required for AMPH-induced DA efflux but not...
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