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Article

Functional analysis of the Mad1-mSin3A repressor-corepressor interaction reveals determinants of specificity, affinity, and transcriptional response.

Molecular and cellular biology - 1 Apr 2004

Cowley Shaun M, Kang Richard S, Frangioni John V, Yada Jason J, DeGrand Alec M, Radhakrishnan Ishwar, Eisenman Robert N

Abstract excerpt

The recruitment of corepressors by DNA-bound repressors is likely to be a critical rate-limiting step in the transcriptional regulation of many genes. An excellent paradigm for such an interaction is the association of the basic helix-loop-helix zipper protein Mad1 with the corepressor mSin3A. When bound together, the Sin3 interaction domain (SID) of Mad1 forms extensive hydrophobic contacts with the four-helix...

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Identifiers

PMID: 15024060
DOI: 10.1128/MCB.24.7.2698-2709.2004
PMCID: PMC371107

Genes

PAH

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Source receipt: pubmed, retrieved 7 Sept 2026.

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