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Article

Protective Functions of ZO-2/Tjp2 Expressed in Hepatocytes and Cholangiocytes Against Liver Injury and Cholestasis.

Gastroenterology - 1 May 2021

Xu Jianliang, Kausalya P Jaya, Van Hul Noémi, Caldez Matias J, Xu Shiyi, Ong Alicia Ghia Min, Woo Wan Lu, Mohamed Ali Safiah, Kaldis Philipp, Hunziker Walter

Abstract excerpt

BACKGROUND & AIMS: Liver tight junctions (TJs) establish tissue barriers that isolate bile from the blood circulation. TJP2/ZO-2-inactivating mutations cause progressive cholestatic liver disease in humans. Because the underlying mechanisms remain elusive, we characterized mice with liver-specific inactivation of Tjp2. METHODS: Tjp2 was deleted in hepatocytes, cholangiocytes, or both. Effects on the liver were...

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PMID: 33465371
DOI: 10.1053/j.gastro.2021.01.027

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