Extensive but hemiallelic methylation of the hMLH1 promoter region in early-onset sporadic colon cancers with microsatellite instability.

doi:10.1016/s1542-3565(03)00314-8

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Article

Extensive but hemiallelic methylation of the hMLH1 promoter region in early-onset sporadic colon cancers with microsatellite instability.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Feb 2004

Miyakura Yasuyuki, Sugano Kokichi, Akasu Takayuki, Yoshida Teruhiko, Maekawa Masato, Saitoh Soh, Sasaki Hideyuki, Nomizu Tadashi, Konishi Fumio, Fujita Shin, Moriya Yoshihiro, Nagai Hideo

Abstract excerpt

BACKGROUND AND AIMS: Methylation of the hMLH1 promoter region is frequently observed in microsatellite instability (MSI)-positive sporadic colorectal carcinomas. We studied hMLH1 promoter methylation in peripheral blood lymphocytes of 87 index patients representing 29 cases of hereditary nonpolyposis colorectal cancers (HNPCCs), 28 cases of atypical HNPCCs, and 30 sporadic cases of the development of early-onset...

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PMID: 15017620
DOI: 10.1016/s1542-3565(03)00314-8

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