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Article

Designing Efficient Double RNA trans-Splicing Molecules for Targeted RNA Repair.

International journal of molecular sciences - 22 Sept 2016

Hüttner Clemens, Murauer Eva M, Hainzl Stefan, Kocher Thomas, Neumayer Anna, Reichelt Julia, Bauer Johann W, Koller Ulrich

Abstract excerpt

RNA trans-splicing is a promising tool for mRNA modification in a diversity of genetic disorders. In particular, the substitution of internal exons of a gene by combining 3' and 5' RNA trans-splicing seems to be an elegant way to modify especially large pre-mRNAs. Here we discuss a robust method for designing double RNA trans-splicing molecules (dRTM). We demonstrate how the technique can be implemented in an...

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Identifiers

PMID: 27669223
DOI: 10.3390/ijms17101609
PMCID: PMC5085642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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