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Article

The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA.

Virology - 5 Jun 2003

Zhou Sifang, Liu Rong, Baroudy Bahige M, Malcolm Bruce A, Reyes Gregory R

Abstract excerpt

The recent development of in vitro hepatitis C virus (HCV) RNA replication systems has provided useful tools for studying the intracellular anti-HCV activity of ribavirin. Ribavirin has been shown to: (1) induce "error catastrophe" in poliovirus, Proc. Natl. Acad. Sci. USA 98, 6895-6900), (2) be a pseudo-substrate of the HCV RNA-dependent RNA polymerase (RdRp) in vitro, J. Biol. Chem. 276, 46094-46098), and (3)...

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Identifiers

PMID: 12781720
DOI: 10.1016/s0042-6822(03)00152-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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