Article
Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes.
The Journal of biological chemistry - 21 May 2004
Yoshizaki Takeshi, Maegawa Hiroshi, Egawa Katsuya, Ugi Satoshi, Nishio Yoshihiko, Imamura Takeshi, Kobayashi Takayasu, Tamura Shinri, Olefsky Jerrold M, Kashiwagi Atsunori
Abstract excerpt
During differentiation, expression of protein phosphatase-2Calpha (PP2Calpha) is increased in 3T3-L1 adipocytes. To elucidate the role of PP2Calpha in insulin signaling, we overexpressed wild-type (WT) PP2Calpha by adenovirus-mediated gene transfer in 3T3-L1 adipocytes. Overexpression of PP2Calpha-WT enhanced the insulin sensitivity of glucose uptake without any changes in the early steps of insulin signaling....
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