Article
Implications of structural and thermodynamic studies of HLA-B27 subtypes exhibiting differential association with ankylosing spondylitis.
Advances in experimental medicine and biology - 1 Jan 2009
Ziegler Andreas, Loll Bernhard, Misselwitz Rolf, Uchanska-Ziegler Barbara
Abstract excerpt
Structural and thermodynamic properties of HLA-B27 molecules provide the basis for their function within the immune system and are probably also central for the understanding of the pathology of HLA-B27-associated diseases such as ankolysing spondylitis (AS). Several HLA-B27 alleles are AS-associated, whereas some are not, although the protein encoded by the former may differ in only a single amino acid exchange...
Topics
- Alleles
- Crystallography, X-Ray
- HLA-B27 Antigen
- Humans
- Models, Molecular
- Molecular Mimicry
- Peptides
- Polymorphism, Genetic
- Protein Conformation
- Protein Isoforms
- Spondylitis, Ankylosing
- Thermodynamics
- Viral Proteins