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Article

Implications of structural and thermodynamic studies of HLA-B27 subtypes exhibiting differential association with ankylosing spondylitis.

Advances in experimental medicine and biology - 1 Jan 2009

Ziegler Andreas, Loll Bernhard, Misselwitz Rolf, Uchanska-Ziegler Barbara

Abstract excerpt

Structural and thermodynamic properties of HLA-B27 molecules provide the basis for their function within the immune system and are probably also central for the understanding of the pathology of HLA-B27-associated diseases such as ankolysing spondylitis (AS). Several HLA-B27 alleles are AS-associated, whereas some are not, although the protein encoded by the former may differ in only a single amino acid exchange...

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Source

Identifiers

PMID: 19731629
DOI: 10.1007/978-1-4419-0298-6_13

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Implications of structural and thermodynamic studies of HLA-B27 subtypes exhibiting differential association with ankylosing spondylitis.PMID 19731629Read ↗

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A single residue exchange between two HLA-B27 alleles triggers increased peptide flexibility.Semantic proximity Read ↗

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Peptide handling by HLA-B27 subtypes influences their biological behavior, association with ankylosing spondylitis and susceptibility to endoplasmic reticulum aminopeptidase 1 (ERAP1).Semantic proximity Read ↗

Peptides: the cornerstone of HLA‐B27 biology and pathogenetic role in spondyloarthritisSemantic proximity Read ↗

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Molecular mechanism of the susceptibility difference between HLA-B*27:02/04/05 and HLA-B*27:06/09 to ankylosing spondylitis: substitution analysis, MD simulation, QSAR modelling, and in vitro assay.Semantic proximity Read ↗

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