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Article

Antiviral activity of KR-23502 targeting nuclear export of influenza B virus ribonucleoproteins.

Antiviral research - 1 Oct 2016

Jang Yejin, Lee Hye Won, Shin Jin Soo, Go Yun Young, Kim Chonsaeng, Shin Daeho, Malpani Yashwardhan, Han Soo Bong, Jung Young-Sik, Kim Meehyein

Abstract excerpt

The spiro compound 5,6-dimethyl-3H,3'H-spiro(benzofuran-2,1'-isobenzofuran)-3,3'-dione (KR-23502) has antiviral activity against influenza A and more potently B viruses. The aim of this study is to elucidate its mechanism of action. Subcellular localization and time-course expression of influenza B viral proteins, nucleoprotein (NP) and matrix protein 1 (M1), showed that KR-23502 reduced their amounts within 5 h...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27565992
DOI: 10.1016/j.antiviral.2016.07.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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