Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of age on circadian rhythms are similar in wild-type and heterozygous Clock mutant mice.

Neurobiology of aging - 1 Apr 2004

Kolker Daniel E, Vitaterna Martha Hotz, Fruechte Ethan M, Takahashi Joseph S, Turek Fred W

Abstract excerpt

The amplitudes of many circadian rhythms, at the behavioral, physiological, cellular, and biochemical levels, decrease with advanced age. Previous studies suggest that the amplitude of the central circadian pacemaker is decreased in old animals. Recently, it has been reported that expression of several circadian clock genes, including Clock, is lower in the master circadian pacemaker of old rodents. To test the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Behavior, Animal
Share to Circadian Rhythm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CLOCK Proteins

Share to Mice, Inbred C57BL

Share to Mice, Mutant Strains

Share to Motor Activity

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 15013573
DOI: 10.1016/j.neurobiolaging.2003.06.007
PMCID: PMC3760160

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of age on circadian rhythms are similar in wild-type and heterozygous Clock mutant mice.PMID 15013573Read ↗

Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice.Semantic proximity Read ↗

Chronotype and stability of spontaneous locomotor activity rhythm in BMAL1-deficient mice.Semantic proximity Read ↗

Restoration of circadian rhythmicity in circadian clock-deficient mice in constant light.Semantic proximity Read ↗

The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude.Semantic proximity Read ↗

Masking responses to light in period mutant mice.Semantic proximity Read ↗

A clock shock: mouse CLOCK is not required for circadian oscillator function.Semantic proximity Read ↗

Suppressed cellular oscillations in after-hours mutant mice are associated with enhanced circadian phase-resetting.Semantic proximity Read ↗

Age and oestrus cycle-related changes in glucocorticoid excretion and wheel-running activity in female mice carrying mutations in the circadian clock genes Per1 and Per2.Semantic proximity Read ↗

The circadian clock and behavior.Semantic proximity Read ↗

Genetic and molecular analysis of wild-derived arrhythmic mice.Semantic proximity Read ↗

Circadian rhythms in murine pups develop in absence of a functional maternal circadian clock.Semantic proximity Read ↗

Loss of circadian rhythmicity in aging mPer1-/-mCry2-/- mutant mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.