Article
Genetic and molecular analysis of wild-derived arrhythmic mice.
PloS one - 1 Jan 2009
Watanabe Tsuyoshi, Suzuki Tohru, Ishikawa Akira, Yokota Yuki, Ueda Hiroki R, Yamada Rikuhiro G, Tei Hajime, Imai Saki, Tomida Shigeru, Kobayashi Junya, Naito Emiko, Yasuo Shinobu, Nakao Nobuhiro, Namikawa Takao, Yoshimura Takashi, Ebihara Shizufumi
Abstract excerpt
A new circadian variant was isolated by screening the intercross offspring of wild-caught mice (Mus musculus castaneus). This variant was characterized by an initial maintenance of damped oscillations and subsequent loss of rhythmicity after being transferred from light-dark (LD) cycles to constant darkness (DD). To map the genes responsible for the persistence of rhythmicity (circadian ratio) and the length of...
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