Article
Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm.
Developmental cell - 1 Aug 2002
Lickert Heiko, Kutsch Stefanie, Kanzler Benoît, Tamai Yoshitaka, Taketo Makoto M, Kemler Rolf
Abstract excerpt
Using Cre/loxP, we conditionally inactivated the beta-catenin gene in cells of structures that exhibit important embryonic organizer functions: the visceral endoderm, the node, the notochord, and the definitive endoderm. Mesoderm formation was not affected in the mutant embryos, but the node was missing, patterning of the head and trunk was affected, and no notochord or somites were formed. Surprisingly, deletion...
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