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Article

Methylation analysis of the imprinted DLK1-GTL2 domain supports the random parental origin of the IGH-involving del(14q) in B-cell malignancies.

Epigenetics - 1 Oct 2009

Katrincsakova Beata, Takeda Haruko, Urbankova Helena, Michaux Lucienne, Jarosova Marie, Vandenberghe Peter, Georges Michel, Charlier Carole, Wlodarska Iwona

Abstract excerpt

Leukemias/lymphomas with IGH-involving del(14q)(1) commonly lose the DLK1-GTL2 imprinted domain that comprises several paternally and maternally expressed genes, including a cluster of microRNAs. Given that deletion of this region could lead to inactivation of a monoallelically expressed tumor su...

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Share to Calcium-Binding Proteins
Share to Chromosomes, Human, Pair 14

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin Heavy Chain

Share to Leukemia, B-Cell

Share to Lymphoma, B-Cell

Share to Methylation

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Share to RNA, Long Noncoding

Source

Identifiers

PMID: 19786834
DOI: 10.4161/epi.4.7.9924

Genes

IGH
DLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19786834-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Methylation analysis of the imprinted DLK1-GTL2 domain supports the random parental origin of the IGH-involving del(14q) in B-cell malignancies.PMID 19786834Read ↗

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