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Article

Sites of protein kinase A activation of the human ClC-2 Cl(-) channel.

The Journal of biological chemistry - 21 May 2004

Cuppoletti John, Tewari Kirti P, Sherry Ann M, Ferrante Christopher J, Malinowska Danuta H

Abstract excerpt

Human ClC-2 Cl(-) (hClC-2) channels are activated by protein kinase A (PKA) and low extracellular pH(o). Both of these effects are prevented by the PKA inhibitor, myristoylated PKI. The aims of the present study were to identify the PKA phosphorylation site(s) important for PKA activation of hClC-2 at neutral and low pH(o) and to examine the relationship between PKA and low pH(o) activation. Recombinant hClC-2...

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PMID: 15010473
DOI: 10.1074/jbc.M312567200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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