RNA editing (R/G site) and flip-flop splicing of the AMPA receptor subunit GluR2 in nervous tissue of epilepsy patients.

doi:10.1016/j.nbd.2003.11.006

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Article

RNA editing (R/G site) and flip-flop splicing of the AMPA receptor subunit GluR2 in nervous tissue of epilepsy patients.

Neurobiology of disease - 1 Mar 2004

Vollmar W, Gloger J, Berger E, Kortenbruck G, Köhling R, Speckmann E-J, Musshoff U

Abstract excerpt

Editing and alternative splicing of mRNA are posttranscriptional steps probably involved in pathophysiological aspects of epilepsy. The present study analyses the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR2 with respect to the expression of (i) editing at the R/G site and (ii) flip-flop cassettes. Nervous tissue from patients with temporal lobe epilepsy was analysed by...

Topics

Adolescent
Adult
Aged
Alternative Splicing
Child
Epilepsy, Temporal Lobe
Exons
Female
Hippocampus
Humans
Male
Middle Aged
Mutation
Neocortex
RNA Editing
RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 15006707
DOI: 10.1016/j.nbd.2003.11.006

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Receptors, AMPA

Reverse Transcriptase Polymerase Chain Reaction