Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors.

doi:10.1016/j.mcn.2007.10.008

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Article

Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors.

Molecular and cellular neurosciences - 1 Feb 2008

Gomes André R, Ferreira Joana S, Paternain Ana V, Lerma Juan, Duarte Carlos B, Carvalho Ana Luísa

Abstract excerpt

Glutamate receptors of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type play an important role in synaptic plasticity and contribute to cell death under excitotoxic conditions. AMPA receptors form heterotetramers of four homologous subunits (GluR1-4), which exist in two functionally different isoforms, flip and flop, generated by alternative splicing. We identified transcripts for...

Topics

Alternative Splicing
Animals
Cell Death
Cell Line
Cells, Cultured
Chick Embryo
Cytoprotection
Epilepsy
Glutamic Acid
Hippocampus
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Protein Isoforms

Protein Structure, Tertiary

Protein Subunits

RNA, Messenger

Rats

Rats, Wistar

Source

Open in PubMed

Identifiers

PMID: 18065236
DOI: 10.1016/j.mcn.2007.10.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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