Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low editing efficiency of GluR2 mRNA is associated with a low relative abundance of ADAR2 mRNA in white matter of normal human brain

1 Jul 2003

Abstract excerpt

The ionotropic glutamate receptor (GluR) subunits GluR2, GluR5 and GluR6 are subject to RNA editing at their Q/R sites, resulting in significant alterations in the channel properties of the receptors. RNA editing at the Q/R site of GluRs is both developmentally and regionally regulated. Here we provide the first quantitative measurements of both mRNAs of the GluR subunits and mRNAs of the RNA editing enzymes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA and protein synthesis mechanisms
Share to RNA regulation and disease
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12859334
DOI: 10.1046/j.1460-9568.2003.02718.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low editing efficiency of GluR2 mRNA is associated with a low relative abundance of ADAR2 mRNA in white matter of normal human brainPMID 12859334Read ↗

Spatio-temporal regulation of ADAR editing during development in porcine neural tissuesSemantic proximity Read ↗

Novel ADAR2 variants in children with seizures, intellectual disability, and motor delay have reduced RNA editing.Semantic proximity Read ↗

RNA editing: a molecular mechanism for the fine modulation of neuronal transmission.Semantic proximity Read ↗

Hippocampus-specific deficiency in RNA editing of GluA2 in Alzheimer's disease.Semantic proximity Read ↗

RNA editing of AMPA receptor subunit GluR-B: A base-paired intron-exon structure determines position and efficiencySemantic proximity Read ↗

Transcript Diversification in the Nervous System: A to I RNA Editing in CNS Function and Disease DevelopmentSemantic proximity Read ↗

ADAR2 affects mRNA coding sequence edits with only modest effects on gene expression or splicing in vivo.Semantic proximity Read ↗

Deregulation of the A-to-I RNA editing mechanism in psychiatric disordersSemantic proximity Read ↗

The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s diseaseSemantic proximity Read ↗

Goldfish brain GluR2: multiple forms, RNA editing, and alternative splicing.Semantic proximity Read ↗

Induced Loss of ADAR2 Engenders Slow Death of Motor Neurons from Q/R Site-Unedited GluR2Semantic proximity Read ↗

Larger intercellular variation in (Q/R) editing of GluR6 than GluR5 revealed by single cell RT-PCR.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.