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Article

A functional polymorphism in the SPINK5 gene is associated with asthma in a Chinese Han Population.

BMC medical genetics - 17 Jun 2009

Liu Qiji, Xia Yu, Zhang Wenjing, Li Jisheng, Wang Pin, Li Huaichen, Wei Chunhua, Gong Yaoqin

Abstract excerpt

BACKGROUND: Mutation in SPINK5 causes Netherton syndrome, a rare recessive skin disease that is accompanied by severe atopic manifestations including atopic dermatitis, allergic rhinitis, asthma, high serum IgE and hypereosinophilia. Recently, single nucleotide polymorphism (SNP) of the SPINK5 was shown to be significantly associated with atopy, atopic dermatitis, asthma, and total serum IgE. In order to...

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Source

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Identifiers

PMID: 19534795
DOI: 10.1186/1471-2350-10-59
PMCID: PMC2709655

Genes

SPINK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome.Semantic proximity Read ↗

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