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Article

Gene polymorphism in Netherton and common atopic disease.

Nature genetics - 1 Oct 2001

Walley A J, Chavanas S, Moffatt M F, Esnouf R M, Ubhi B, Lawrence R, Wong K, Abecasis G R, Jones E Y, Harper J I, Hovnanian A, Cookson W O

Abstract excerpt

Atopic dermatitis (AD) and asthma are characterized by IgE-mediated atopic (allergic) responses to common proteins (allergens), many of which are proteinases. Loci influencing atopy have been localized to a number of chromosomal regions, including the chromosome 5q31 cytokine cluster. Netherton disease is a rare recessive skin disorder in which atopy is a universal accompaniment. The gene underlying Netherton...

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Topics

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Share to Asthma
Share to Carrier Proteins
Share to Dermatitis, Atopic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Primers

Share to Proteinase Inhibitory Proteins, Secretory

Share to Sequence Homology, Amino Acid

Share to Serine Peptidase Inhibitor Kazal-Type 5

Share to Serine Proteinase Inhibitors

Source

Identifiers

PMID: 11544479
DOI: 10.1038/ng728

Genes

SPINK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Gene polymorphism in Netherton and common atopic disease.PMID 11544479Read ↗

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The 420K LEKTI variant alters LEKTI proteolytic activation and results in protease deregulation: implications for atopic dermatitisSemantic proximity Read ↗

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