Article
Immunomodulation with CD40 stimulation and interleukin-2 protects mice from disseminated cryptococcosis.
Infection and immunity - 1 Apr 2006
Zhou Qing, Gault Ruth A, Kozel Thomas R, Murphy William J
Abstract excerpt
Cryptococcus neoformans is a ubiquitous fungus that can cause life-threatening infections during immunosuppressive states such as AIDS and after bone marrow transplantation. In this study we investigated the antifungal efficacy of an agonist antibody to CD40, an important costimulator of immune function, in combination with interleukin 2 (IL-2) in a murine model of disseminated cryptococcosis. Only the...
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