Spontaneous mutations decrease sensitivity of gene expression to random environmental variation in Caenorhabditis elegans.

Abstract excerpt

BACKGROUND: Biological phenotypes are described as "canalized" if they are robust to minor variation of environment and/or genetic background. The existence of a robust phenotype logically implies that some underlying mechanism must be variable, in the sense of "able to vary", in order to compensate for variation in the environment and/or genetic effects. Several lines of evidence lead to the conclusion that...

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